2024
Preclinical side effect prediction through pathway engineering of protein interaction network models
Alidoost, M, Wilson, JL. CPT: Pharmacometrics & Systems Pharmacology. 2024 May 12.
2023
Drug target, class level, and PathFX pathway information share utility for machine learning prediction of common drug-induced side effects
Liu, HJ, Wilson, JL. Front. Drug Saf. Regul. 2023 Nov 23; 3.
An electronic health record cohort of Veterans with amyotrophic lateral sclerosis
Reimer, RJ, Goncalves, A, Soper, B, Cadena, J, Wilson, JL, Gryshuk, AL, Suarez, P, Osborne, T, Grimes, KG, Ray, P. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 2023 24(7–8), 695–701.
Model utility of a deep learning-based segmentation is not Dice coefficient dependent: A case study in volumetric brain blood vessel segmentation
Alidoost, M, Ghodrati, V, Ahmadian, A, Shafiee, A, Hassani, CH, Bedayat, A, Wilson, JL. Intelligence-Based Medicine. 2023; 7:1000092
Beta2 adrenoceptor agonism alters astrocyte phagocytic activity and has potential applications to psychiatric disease
Bowen, ER, DiGiacomo, P, Fraser, HP, Guttenplan, K, Smith, BAH, Heberling, M, Vidano, L, Shah, N, Shamloo, M, Wilson, JL+, Grimes, KJ.+.Discov Ment Health. 2023 Nov 30;3(1):27. doi: 10.1007/s44192-023-00050-5.
+ indicates co-corresponding author
2022
A network paradigm predicts drug synergistic effects using downstream protein-protein interactions
Wilson JL, Steinberg E, Racz R, Altman RB, Shah N, Grimes K. CPT Pharmacometrics Syst Pharmacol. Oct 6.
Controlling astrocyte-mediated synaptic pruning signals for schizophrenia drug repurposing with deep graph networks
Gravina A, Wilson JL, Bacciu D, Grimes KJ, Priami C. PLoS Comput Biol. May;18(5).
From random to predictive: a context-specific interaction framework improves selection of drug protein-protein interactions for unknown drug pathways
Wilson JL, Gravina A, Grimes K. Integr Biol. Mar 21;14(1).
2021
PhenClust, a standalone tool for identifying trends within sets of biological phenotypes using semantic similarity and the Unified Medical Language System metathesaurus
Wilson JL, Wong M, Stepanov N, Petkovic D, Altman R. JAMIA Open. Jul;4(3).
2020
Scientific considerations for global drug development
Jennifer L Wilson, Kit Wun Kathy Cheung, Lawrence Lin, Elizabeth AE Green, Analia I Porrás, Ling Zou, David Mukanga, Paul A Akpa, Delese Mimi Darko, Rae Yuan, Sheng Ding, Wiltshire CN Johnson, Howard A Lee, Emer Cooke, Carl C Peck, Steven E Kern, Dan Hartman, Yoshikazu Hayashi, Peter W Marks, Russ B Altman, Murray M Lumpkin, Kathleen M Giacomini, Terrence F Blaschke
Science Translational Medicine 12 (554).
An in vitro quantitative systems pharmacology approach for deconvolving mechanisms of drug-induced, multilineage cytopenias
2019
PathFXweb: a web application for identifying drug safety and efficacy phenotypes
JL Wilson, M Wong, A Chalke, N Stepanov, D Petkovic, RB Altman
Bioinformatics 35 (21), 4504-4506
An Overview of Genomic Biomarker Use in Cardiovascular Disease Clinical Trials
Oluseyi Adeniyi, Anuradha Ramamoorthy, Robert Schuck, Jielin Sun, Jennifer Wilson, Issam Zineh, Michael Pacanowski
Clinical Pharmacology & Therapeutics 106 (4), 841-846
Evaluating Angiogenic Potential of Small Molecules Using Genetic Network Approaches
Anusuya Das, Parker Merrill, Jennifer Wilson, Thomas Turner, Mikell Paige, Scott Capitosti, Milton Brown, Brandon Freshcorn, Mary Caitlin P Sok, Hannah Song, Edward A Botchwey
2018
PathFX provides mechanistic insights into drug efficacy and safety for regulatory review and therapeutic development
Jennifer L Wilson, Rebecca Racz, Tianyun Liu, Oluseyi Adeniyi, Jielin Sun, Anuradha Ramamoorthy, Michael Pacanowski, Russ Altman
PLoS computational biology 14 (12), e1006614
A scientist engineer’s contribution to therapeutic discovery and development
JL Wilson
Experimental Biology and Medicine 243 (14), 1125-1132
Biomarkers: Delivering on the expectation of molecularly driven, quantitative health
JL Wilson, RB Altman
Experimental Biology and Medicine 243 (3), 313-322
Functional Genomics Approach Identifies Novel Signaling Regulators of TGFα Ectodomain Shedding
Jennifer L Wilson, Eirini Kefaloyianni, Lauren Stopfer, Christina Harrison, Venkata S Sabbisetti, Ernest Fraenkel, Douglas A Lauffenburger, Andreas Herrlich
Molecular Cancer Research 16 (1), 147-161
2016
Pathway-based network modeling finds hidden genes in shRNA screen for regulators of acute lymphoblastic leukemia
JL Wilson, S Dalin, S Gosline, M Hemann, E Fraenkel, DA Lauffenburger
Integrative Biology 8 (7), 761-774
2013 and earlier
Integrated network analyses for functional genomic studies in cancer
JL Wilson, MT Hemann, E Fraenkel, DA Lauffenburger
Seminars in cancer biology 23 (4), 213-218