Reviews: promiscuous ribozymes, HTS, and fitness landscapes
It is tempting to imagine that, during the origin of life, the earliest catalytic RNAs would be so simple that they would be rather non-specific in activity or substrates. Then, evolution might create variants that would become optimized for different activities...
Controlled phage therapy
Phages have been considered for antibacterial therapy ever since they were discovered in the early 20th century. However, significant concerns about their self-replicating, evolving nature have been difficult to avoid. For example, phages can spread antibiotic...
RNA on the early earth: damaged by light, helped by vesicles
RNA is widely agreed to be an early, if not the earliest, molecular basis for life. However, conditions on the early Earth were not terribly hospitable. While high-energy photons are important for prebiotic synthesis, they also damage nucleic acids. Postdoctoral...