Why do phages tolerate molecular engineering?

Why do phages tolerate molecular engineering?

When Huan Peng first cloned M13 chimeras by mix-and-match with other filamentous phages, in order to change the host targeted, we thought we’d probably need to do at least a little directed evolution to improve the folding or affinity of the new chimeras. That...
Thesis defense: Dr. Tran

Thesis defense: Dr. Tran

Congratulations to Dr. Claire Tran on successfully defending her thesis! We will miss her hard-won expertise in protein and RNA biochemistry as well as her carefully crafted ‘joke’ slides. Dr. Tran is heading to Boston to join i2o Therapeutics.
Processing Illumina data from in vitro evolution

Processing Illumina data from in vitro evolution

A few years ago, Celia Blanco and Sam Verbanic began analyzing Illumina data from our collaborator Burckhard Seelig’s laboratory. Since our existing tools were written for ribozyme selections, Celia and Sam wrote some new scripts to pre-process the data. Others...